Publications

NAR Cancer

Loss of ribosomal protein uL14 enables tumor escape from T cell immunosurveillance

Dopler, A., Kyei-Baffour, E.S., Kerkhoff, M., Alkan, F., Malka, Y., Hoefakker, K., van der Kammen, R., Hoekman, L., Bleijerveld, O., Bradaric, A., et al. (2025).

Immunity

Adoptive T-cell therapy targeting a broadly shared, inducible product of aberrant mRNA translation

Champagne J, Nielsen MM, Feng X, Montenegro Navarro J, Pataskar A, Voogd R, Giebel L, Nagel R, Berenst N, Fumagalli A, Kochavi A, Lovecchio D, Valcanover L, Malka Y, Yang W, Laos M, Li Y, Proost N, van de Ven M, van Tellingen O, Bleijerveld OB, Haanen JBAG, Olweus J, Agami R. (2024).

Nucleic Acids Res.

Chemotherapeutic agents and leucine deprivation induce codon-biased aberrant protein production in cancer

Kochavi, A., Nagel, R., Körner, P.R., Bleijerveld, O., Lin, C.P., Huinen, Z., Malka, Y., Proost, N., van de Ven, M., Feng, X., Montenegro N.J., Pataskar, A., Peeper, D., Champagne, J., Agami, R. (2024)

P-stalk ribosomes act as master regulators of cytokine-mediated processes‏

Dopler, A., Alkan, F., Malka, Y., Hoefakker, K., Isaeva, O., Kerkhoff, M., Gangaev, A., Silva, J., Ramalho, S., Van der Kammen, R., Kok, M., Yewdel, J., Kvistborg, P., Faller W.J. P-stalk ribosomes act as master regulators of cytokine-mediated processes. (2024)

Cell

Science

DNA damage induces TP53-independent apoptosis through TTA-codon ribosome stalling

Boon, N.J., Kochavi, A., Mertens, S., Körner, P.R., Malka, Y., Van der Horst, S., Draper, J.M., Wessels, L.F.A., Haahr, P., Snippert, H.J., Agami R and Brummelkamp T.R. 2024.

Cancer Cell

Multimodal stimulation screens reveal unique and shared genes limiting T-cell fitness

Lin, C.P., Levy P., Alflen, A., Apriamashvili, G., Ligtenberg, M., Vredevoogd, D.W., Bleijerveld, O., Alkan, F., Malka, Y., Hoekman, L., Markovits, E., Traets, J.J.H., George, A., Krijgsman, O., Van Vliet, A., De Bruijn, B., Van Hal-van Veen, S., Visser, N.L., Van der Helm, P., Gomez, J.D., Warda, H., Behrens, L., Mardesic, P., Dehni, B., Markel, G., Faller, W.J., Altelaar, M., Agami, R., Besser, M.J., Peeper, D.S. (2024)

BioRxiv
(Under Revision)

RNA dicing regulates the expression of an oncogenic JAK1 isoform

Van der Kammen, R., Ju, S., Alkan, F., Lee, C., Faller, W.J., Malka, Y. (2024).

J Exp Med.

MYC is a clinically significant determinant of mTOR inhibitor resistance in breast cancer

Bhin, J., Yemelyanenko, J., Chao, X., Klarenbeek, S., Opdam, M., Malka, Y., Hoekman, L., Kruger, D., Bleijerveld, O., Brambillasca, C.S., Sprengers, J., Siteur, B., Annunziato, S., Van Haren, M.J., Martin, N.I., Van de Ven, N., Peters, D., Agami, R., Linn, S.C., Boven, E., Altelaar, M., Jonkers, J., Zingg, D. and Wessels, L.F.A. (2023).

Molecular Cell

Alternative cleavage and polyadenylation generates downstream uncapped RNA isoforms with translation potential

Malka, Y., Alkan, F., Ju, S., Körner, P.R., Pataskar, A., Shulman, E., Loayza-Puch, F., Champagne, J., Wenzel, C., Faller, W.J., Elkon, R., Lee, C., Agami, R. (2022).

Research Highlight on this paper: Heinke, L. Exploring the uncharted landscape of truncated mRNAs. Nat Rev Mol Cell Biol . https://doi.org/10.1038/s41580-022-00561-z. (2022)

Nature Comm.

Post-transcriptional 3 -UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments

Malka, Y., Steiman-Shimony, A., Rosenthal, E., Argaman, L., Cohen-Daniel, L., Arbib, E., Margalit, H., Kaplan, T., and Berger, M. (2017).

PLoS Genet.

Synergistic interactions between the molecular and neuronal circadian networks drive robust behavioral circadian rhythms in Drosophila melanogaster

Weiss, R., Bartok, O., Mezan, S., Malka, Y., and Kadener, S. (2014).

Cytometry Part A

Analysis of apoptosis in FUCCI HeLa cells

Malka, Y., and Eden, S. (2011).